Die Vortragsreihe Medizinische Forschung der Medizinischen Fakultät OWL findet im Wintersemester 2025/2026 an verschiedenen Terminen jeweils mittwochs um 12:00 bzw. 17:00 Uhr (~1Std.) als Zoom-Videokonferenz oder im hybriden Format in Seminarräumen der Universität Bielefeld statt.
Die Veranstaltung bietet spannende Impulse durch interne und externe Sprecher*innen und dient gleichzeitig als Plattform zum interdisziplinären Austausch im Bereich der medizinischen und medizinrelevanten Forschung.
Vortragender: Dr. Nils Hoffmann, Computergestützte Metagenomik des Instituts für Bio- und Geowissenschaften,
Forschungszentrum Jülich, Universität Bielefeld
Titel: Enabling FAIR Comparative Lipidomics with LipidCompass
Abstract
Lipids are vital to biological systems, with disturbances in lipid homeostasis linked to various diseases. Despite the advancements in lipidomics, the field lacks a central reference point for the occurrence and concentration of lipids. We introduce LipidCompass, a community-driven repository, aligned with the FAIR principles, to simplify discovery, comparison and visualization of lipidomic data from various sources, opening up new perspectives and potentially advancing the field of lipidomics research.
The input data format, mzTab-M, allows study data to be mapped to standardized terminology defined by controlled vocabularies such as NCIT and PSI-MS. The embedded lipid nomenclature converter, Goslin, translates lipid names into the latest lipidomics shorthand nomenclature, facilitating cross-linking to public databases like LIPID MAPS, SwissLipids, and ChEBI. Additionally, data is represented according to the hierarchical levels of the shorthand lipid nomenclature, enabling comparisons of studies measured at different structural resolutions at the most common level.
The initial studies included as a starting point encompass more than 11,000 distinct lipids across all hierarchical lipid levels, highlighting LipidCompass’s potential for large-scale comparative data analysis. Consequently, LipidCompass serves as a comprehensive knowledge base on qualitative and quantitative lipid diversity across different species, tissues, and conditions.
As a central component of the Lipidomics Informatics for Life-Science (LIFS) project, LipidCompass will integrate with services like LipidXplorer and LipidSpace. Collaborations with the International Lipidomics Society will further enhance standardization, integrating support for the lipidomics checklist, leveraging a community-guided reviewing and curation model and thereby solidifying LipidCompass as a reference resource in comparative lipidomics.